A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing

Mitogen-activated protein kinases (MAPKs) including Erk, Jnk and p38 regulate diverse cellular functions and are thought to be controlled by independent upstream activation cascades. Here we show that the sestrins bind to and coordinate simultaneous Erk, Jnk and p38 MAPK activation in T lymphocytes...

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Bibliographic Details
Main Authors: Lanna, A, Gomes, D, Muller-Durovic, B, McDonnell, T, Escors, D, Gilroy, D, Lee, J, Karin, M, Akbar, A
Format: Journal article
Published: Springer Nature 2017