Phenotypic models of perfect adaptation by CD8+ T cells

<p>T cells receive continuous antigenic stimulation in peripheral tolerance, cancer, and chronic infection. Persistent antigen exposure induces an initial cellular response. However, over time, T cells become unresponsive to the stimulus and cease activity, a behaviour known as adaptation. Alt...

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Bibliographic Details
Main Author: Gaglione, SA
Other Authors: Dushek, O
Format: Thesis
Language:English
Published: 2019