Cohesin: a catenase with separate entry and exit gates?

Cohesin: a catenase with separate entry and exit gates?

Cohesin confers both intrachromatid and interchromatid cohesion through formation of a tripartite ring within which DNA is thought to be entrapped. Here, I discuss what is known about the four stages of the cohesin ring cycle using the ring model as an intellectual framework. I postulate that cohesi...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Nasmyth, K
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2011

Eitemau Tebyg

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Cohesin: its roles and mechanisms.
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Cohesin's concatenation of sister DNAs maintains their intertwining.
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The cohesin ring concatenates sister DNA molecules.
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Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei.
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Scc2/Nipbl hops between chromosomal cohesin rings after loading.
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Cohesin can remain associated with chromosomes during DNA replication
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Cohesin regulates T cell receptor rearrangement and thymocyte differentiation
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DNA passes through cohesin’s hinge as well as its Smc3–kleisin interface
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Sister DNA entrapment between juxtaposed Smc heads and kleisin of the cohesin complex
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Scc2/Nipbl hops between chromosomal cohesin rings after loading
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Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit.
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Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge.
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Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis.
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How cohesin regulates gene expression and differentiation in non-dividing mammalian cells
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Water entry and exit of axisymmetric bodies by CFD approach
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A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands.
gan: Pauli, A, et al.
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What AlphaFold tells us about cohesin’s retention on and release from chromosomes
gan: Kim A Nasmyth, et al.
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Cohesin Can Remain Associated with Chromosomes during DNA Replication
gan: James D.P. Rhodes, et al.
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Determinants of Net Entry and Exit in Iran’s Manufacturing Industries
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Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.
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