GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension

Manylion Llyfryddiaeth
Prif Awduron:	Khoo, J, Zhao, L, Alp, N, Bendall, J, Nicoll, T, Wilkins, MR, Channon, K
Fformat:	Conference item
Cyhoeddwyd:	2004

Eitemau Tebyg

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
gan: Bendall, J, et al.
Cyhoeddwyd: (2004)

GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
gan: Tatham, A, et al.
Cyhoeddwyd: (2009)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
gan: Chuaiphichai, S, et al.
Cyhoeddwyd: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
gan: Chuaiphichai, S, et al.
Cyhoeddwyd: (2014)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
gan: Alp, N, et al.
Cyhoeddwyd: (2003)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
gan: Alp, N, et al.
Cyhoeddwyd: (2003)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
gan: Khoo, J, et al.
Cyhoeddwyd: (2004)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
gan: Chuaiphichai, S, et al.
Cyhoeddwyd: (2014)

Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension
gan: Du, Y, et al.
Cyhoeddwyd: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension\
gan: Du, Y, et al.
Cyhoeddwyd: (2005)

Endothelial-specific GTP cyclohydrolase I overexpression prevents blood pressure progression in salt-sensitive hypertension
gan: Chen, A, et al.
Cyhoeddwyd: (2005)

Cardiomyocyte-targeted overexpression of GTP cyclohydrolase-1 increases nNOS activity and hastens myocardial relaxation
gan: Carnicer, R, et al.
Cyhoeddwyd: (2011)

Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
gan: Adlam, D, et al.
Cyhoeddwyd: (2007)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
gan: Alp, N, et al.
Cyhoeddwyd: (2003)

Endothelial-specific GTP cyclohydrolase overexpression reduces blood pressure in salt-sensitive hypertension
gan: Chen, A, et al.
Cyhoeddwyd: (2006)

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
gan: Ryan, B, et al.
Cyhoeddwyd: (2014)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
gan: Carnicer, R, et al.
Cyhoeddwyd: (2012)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
gan: Carnicer, R, et al.
Cyhoeddwyd: (2012)

Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
gan: Du, Y, et al.
Cyhoeddwyd: (2008)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
gan: Khoo, J, et al.
Cyhoeddwyd: (2004)

GTP Cyclohydrolase/BH4 Pathway Protects EPC Function via Suppressing Oxidative Stress and Thrombospondin-1 in Salt-Sensitive Hypertension
gan: Xie, H, et al.
Cyhoeddwyd: (2009)

GTP cyclohydrolase II structure and mechanism.
gan: Ren, J, et al.
Cyhoeddwyd: (2005)

GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension
gan: Xie, H, et al.
Cyhoeddwyd: (2010)

GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.
gan: Xie, H, et al.
Cyhoeddwyd: (2010)

Decreased Cardiac Allograft Rejection in Mice Over-Expressing Human GTP Cyclohydrolase I.
gan: Irina, I, et al.
Cyhoeddwyd: (2009)

Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes.
gan: Tie, L, et al.
Cyhoeddwyd: (2009)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I over-expression
gan: Alp, N, et al.
Cyhoeddwyd: (2003)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
gan: Alp, N, et al.
Cyhoeddwyd: (2004)

Cardiomyocyte-Targeted Overexpression of GTP Cyclohydrolase-1 Increases Myocyte Lusitropy and Reduces Superoxide Production
gan: Carnicer, R, et al.
Cyhoeddwyd: (2010)

Endothelium-targeted GTP cyclohydrolase I overexpression inhibits wire injury-induced restenosis in mouse carotid artery
gan: Chen, A, et al.
Cyhoeddwyd: (2005)

Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1.
gan: Wang, W, et al.
Cyhoeddwyd: (2008)

Systemic adenovirus-mediated gene transfer of human GTP cyclohydrolase-1 increases liver, plasma and aortic tetrahydrobiopterin levels in mice
gan: Alp, N, et al.
Cyhoeddwyd: (2002)

GTP cyclohydrolase I prevents diabetic-impaired endothelial progenitor cells and wound healing by suppressing oxidative stress/thrombospondin-1.
gan: Tie, L, et al.
Cyhoeddwyd: (2014)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
gan: Khoo, J, et al.
Cyhoeddwyd: (2005)

GTP cyclohydrolase as a novel mechanism for tumour growth
gan: Chen, L, et al.
Cyhoeddwyd: (2015)

The protein partners of GTP cyclohydrolase I in rat organs.
gan: Jianhai Du, et al.
Cyhoeddwyd: (2012-01-01)

Assay for GTP Cyclohydrolase II Activity in Bacterial Extracts
gan: Svetlana Yurgel, et al.
Cyhoeddwyd: (2014-08-01)

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.
gan: Cai, S, et al.
Cyhoeddwyd: (2002)

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.
gan: Khoo, J, et al.
Cyhoeddwyd: (2005)

GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats.
gan: Meininger, C, et al.
Cyhoeddwyd: (2004)