GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension

Geahča maid

• Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
  Dahkki: Bendall, J, et al.
  Almmustuhtton: (2004)
• GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
  Dahkki: Tatham, A, et al.
  Almmustuhtton: (2009)
• Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
  Dahkki: Chuaiphichai, S, et al.
  Almmustuhtton: (2014)
• Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
  Dahkki: Chuaiphichai, S, et al.
  Almmustuhtton: (2014)
• Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
  Dahkki: Alp, N, et al.
  Almmustuhtton: (2003)