CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho famil...

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Detalles Bibliográficos
Main Authors: Michel, F, Acuto, O
Formato: Journal article
Idioma:English
Publicado: 2002