CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?
T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho famil...
| Main Authors: | , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2002
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