Developing genome-editing strategies to ameliorate HbE/beta-thalassaemia

<p>The thalassaemias are the most common monogenic disorders worldwide. Both α- and β-thalassaemia are caused by genetic mutations that result in a decrease in globin gene expression and protein synthesis. The more clinically significant of the two disorders, β-thalassaemia is mainly caused by...

Полное описание

Библиографические подробности
Главный автор: Badat, M
Другие авторы: Higgs, D
Формат: Диссертация
Язык:English
Опубликовано: 2021