X-ray studies on the mechanism of IPNS using substrate analogs
The substrate analog L-S-(a-aminoadipoyl)-L-cysteinyl-glycine (ACG) was co-crystallised with isopenicillin N synthase using the hanging-drop vapourdiffusion method in an anaerobic environment. ' X-ray crystallography revealed a different mode of binding for ACG compared to the natural substrate...
Main Authors: | Long, A, Clifton, I, Roach, P, Schofield, C, Baldwin, J, Hajdu, J |
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Format: | Journal article |
Jezik: | English |
Izdano: |
1997
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