TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia

TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia

Chronic myelomonocytic leukemia (CMML) has recently been associated with a high incidence of diverse mutations in genes such as TET2 or EZH2 that are implicated in epigenetic mechanisms. We have performed genome-wide DNA methylation arrays and mutational analysis of TET2, IDH1, IDH2, EZH2 and JAK2 i...

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Hauptverfasser: Pérez, C, Martínez-Calle, N, Martín-Subero, J, Segura, V, Delabesse, E, Fernandez-Mercado, M, Garate, L, Alvarez, S, Rifon, J, Varea, S, Boultwood, J, Wainscoat, J, Cruz Cigudosa, J, Calasanz, M, Cross, N, Prósper, F, Agirre, X
Format: Journal article
Sprache:English
Veröffentlicht: Public Library of Science 2012

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