Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

Signal integration between activating Fc receptors and inhibitory signal regulatory protein α (SIRPα) controls macrophage phagocytosis. Here, using dual-color direct stochastic optical reconstruction microscopy, we report that Fcγ receptor I (FcγRI), FcγRII, and SIRPα are not homogeneously distribut...

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Bibliographic Details
Main Authors: Lopes, F, Bálint, Š, Valvo, S, Felce, J, Hessel, E, Dustin, M, Davis, D
Format: Journal article
Language:English
Published: Rockefeller University Press 2017