Determining the most appropriate components for a composite clinical trial outcome.

BACKGROUND: Because composite end points augment event rates, they are often thought to increase statistical power. This may not be true if the intervention has a lesser effect on some components of the composite. Consequently, treatment effect size may depend on the choice of composite. METHODS: T...

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Bibliographic Details
Main Authors: Bethel, M, Holman, R, Haffner, S, Califf, R, Huntsman-Labed, A, Hua, T, McMurray, J
Format: Journal article
Language:English
Published: 2008