STUDIES ON THE MECHANISM OF DEACETOXY DEACETYLCEPHALOSPORIN-C SYNTHASE USING CYCLOPROPYL SUBSTITUTED CEPHALOSPORIN PROBES

STUDIES ON THE MECHANISM OF DEACETOXY DEACETYLCEPHALOSPORIN-C SYNTHASE USING CYCLOPROPYL SUBSTITUTED CEPHALOSPORIN PROBES

Cyclopropyl substituted cephalosporin analogues were prepared and evaluated as substrates for the Fe II/α-ketoglutarate dependent oxygenase, DAOC-DAC synthase; the first example of catalytic product formation from a Cyclopropyl ring cleavage pathway by an α-ketoglutarate dependent oxygenase is repor...

Full description

Bibliographic Details
Main Authors:	Baldwin, J, Adlington, R, Crouch, N, Keeping, J, Leppard, S, Pitlik, J, Schofield, C, Sobey, W, Wood, M
Format:	Journal article
Published:	1991

Similar Items

Studies on deacetoxy/deacetylcephalosporin C synthase
by: Pereira, I, et al.
Published: (1993)

Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase.
by: Baldwin, J, et al.
Published: (1992)

Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase.
by: Baldwin, J, et al.
Published: (1988)

THE ENZYMATIC CONVERSION OF EXOMETHYLENE CEPHALOSPORIN-C INTO DEACETYL CEPHALOSPORIN-C AND THE ROLE OF MOLECULAR-OXYGEN IN CEPHALOSPORIN-C BIOSYNTHESIS
by: Baldwin, J, et al.
Published: (1988)

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.
by: Lloyd, MD, et al.
Published: (2004)

THE ROLE OF ALPHA-KETOGLUTARATE IN CEPHALOSPORIN BIOSYNTHESIS
by: Baldwin, J, et al.
Published: (1989)

THE ROLE OF MOLECULAR-OXYGEN IN CEPHALOSPORIN-C BIOSYNTHESIS
by: Baldwin, J, et al.
Published: (1987)

Structure of a cephalosporin synthase.
by: Valegård, K, et al.
Published: (1998)

ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
by: Baldwin, J, et al.
Published: (1987)

CEPHALOSPORIN BIOSYNTHESIS - A BRANCHED PATHWAY SENSITIVE TO AN ISOTOPE EFFECT
by: Baldwin, J, et al.
Published: (1991)

CEPHALOSPORIN-C BIOSYNTHESIS - A BRANCHED PATHWAY SENSITIVE TO A KINETIC ISOTOPE EFFECT
by: Baldwin, J, et al.
Published: (1987)

Syntheses of (6S)-cephalosporins from 6-aminopenicillanic acid
by: Fekner, T, et al.
Published: (2000)

CEPHALOSPORIN-C BIOSYNTHESIS - STEREOCHEMISTRY OF THE INCORPORATION OF D,L,D-ALPHA-AMINODIPOYL-CYSTEINYL-(3S)-[2-2H,4-C-13]VALINE INTO BETA-LACTAM COMPOUNDS
by: Baldwin, J, et al.
Published: (1989)

THE ROLE OF SULFUR IN CEPHALOSPORIN BIOSYNTHESIS
by: Baldwin, J, et al.
Published: (1991)

THE ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
by: Baldwin, J, et al.
Published: (1987)

Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
by: Wu, Xiaojin, et al.
Published: (2018)

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
by: Dubus, A, et al.
Published: (2001)

CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS
by: Baldwin, J, et al.
Published: (1995)

Stereoselective Alder-ene reactions of bicyclo[1.1.0]butanes: facile synthesis of cyclopropyl- and aryl-substituted cyclobutenes
by: Dasgupta, A, et al.
Published: (2023)

GAMMA-LACTAM FORMATION FROM TRIPEPTIDES WITH ISOPENICILLIN-N SYNTHASE
by: Baldwin, J, et al.
Published: (1988)

Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.
by: Baldwin, J, et al.
Published: (1987)

The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives.
by: Tsang, W, et al.
Published: (2004)

AN EFFECTIVE SUBSTITUTE FOR ALPHA-AMINOADIPIC ACID IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS
by: Baldwin, J, et al.
Published: (1987)

ENZYMATIC-SYNTHESIS OF BICYCLIC GAMMA-LACTAMS USING CLAVAMINIC ACID SYNTHASE
by: Baldwin, J, et al.
Published: (1992)

Chemo-enzymatic synthesis of bicyclic gamma-lactams using clavaminic acid synthase
by: Baldwin, J, et al.
Published: (1997)

Are anthocyanidins the immediate products of anthocyanidin synthase?
by: Turnbull, J, et al.
Published: (2000)

AN EFFICIENT SUBSTITUTE FOR THE ALPHA-AMINOADIPOYL MOIETY OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS
by: Baldwin, J, et al.
Published: (1987)

Empirical cephalosporin treatment of melioidosis.
by: Chaowagul, W, et al.
Published: (1999)

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
by: Daruzzaman, A, et al.
Published: (2013)

EXAFS STUDIES OF ISOPENICILLIN-N SYNTHASE
by: Randall, C, et al.
Published: (1992)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
by: Baldwin, J, et al.
Published: (1991)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
by: Baldwin, J, et al.
Published: (1992)

An unprecedented alpha-C-C agostic interaction in a cyclopropyl tris(pyrazolyl)boratoniobium complex.
by: Jaffart, J, et al.
Published: (2003)

Enzyme responsive luminescent ruthenium(II) cephalosporin probe for intracellular imaging and photoinactivation of antibiotics resistant bacteria
by: Shao, Qing, et al.
Published: (2013)

AN INVESTIGATION INTO THE MECHANISM OF ELASTASE INHIBITION BY CEPHALOSPORINS USING ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY
by: Aplin, R, et al.
Published: (1993)

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
by: Ge, W, et al.
Published: (2010)

STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C
by: Baldwin, J, et al.
Published: (1987)

8-Cyclopropyl-2′-Deoxyguanosine: a hole trap for DNA-mediated charge transport
by: Wong, Jiun Ru, et al.
Published: (2014)

REVISED STRUCTURES FOR TU 1718B AND VALCLAVAM
by: Baldwin, J, et al.
Published: (1993)

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
by: Ge, W, et al.
Published: (2010)