Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Canonical roles for macrophages in mediating the fibrotic response after a heart attack include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen deposition. Here we reveal that macrophages directly contribute collagen to the forming post-injury scar. Unbiased...

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Bibliographic Details
Main Authors: Simoes, FC, Cahill, TJ, Kenyon, A, Gavriouchkina, D, Vieira, JM, Sun, X, Pezzolla, D, Ravaud, C, Masmanian, E, Weinberger, M, Mayes, S, Lemieux, ME, Barnette, DN, Gunadasa-Rohling, M, Williams, R, Greaves, DR, Trinh, LA, Fraser, SE, Dallas, SL, Choudhury, RP, Sauka-Spengler, T, Riley, PR
Format: Journal article
Language:English
Published: Springer Nature 2020