Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a gen...

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Autors principals: Lees, J, Ferwerda, B, Kremer, PHC, Wheeler, N, Serón, M, Croucher, N, Gladstone, R, Bootsma, H, Rots, N, Wijmega-Monsuur, A, Sanders, EAM, Trzciński, K, Wyllie, A, Zwinderman, A, Van Den Berg, L, Van Rheenen, W, Veldink, J, Harboe, Z, Lundbo, L, De Groot, LCPGM, Van Schoor, N, Van Der Velde, N, Ängquist, L, Sørensen, TIA, Nohr, E, Mentzer, A, Mills, T, Knight, JC, Du Plessis, M, Nzenze, S, Weiser, J, Parkhill, J, Madhi, S, Benfield, T, Von Gottberg, A, Van Der Ende, A, Brouwer, M, Barrett, J, Bentley, S, Van De Beek, D
Format: Journal article
Publicat: Springer Nature 2019
Matèries:
bacterial genes
genome-wide association studies
immunogenetics
bacterial infection

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