Fatty acids prevent Hypoxia-Inducible Factor 1α signalling through decreased succinate in diabetes

<p>Hypoxia-inducible factor 1α (HIF1α) is activated following myocardial infarction (MI), and is critical for cardiomyocyte survival in hypoxia. Patients with type 2 diabetes have poorer prognosis post-MI, which is associated with abnormal cardiac fatty acid (FA) metabolism. We questioned whet...

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Bibliographic Details
Main Authors: Dodd, M, Sousa Fialho, M, Montes Aparicio, C, Kerr, M, Timm, K, Griffin, J, Luiken, J, Glatz, J, Tyler, D, Heather, L
Format: Journal article
Published: Elsevier 2018