Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

During mitosis, the formation of microtubule–kinetochore attachments is monitored by the serine/threonine kinase monopolar spindle 1 (MPS1). MPS1 is recruited to unattached kinetochores where it phosphorylates KNL1, BUB1, and MAD1 to initiate the spindle assembly checkpoint. This arrests the cell cy...

Полное описание

Библиографические подробности
Главные авторы:	Hayward, D, Bancroft, J, Mangat, D, Alfonso-Pérez, T, Dugdale, S, McCarthy, J, Barr, FA, Gruneberg, U
Формат:	Journal article
Язык:	English
Опубликовано:	Rockefeller University Press 2019

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