Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme deficiency are the genetic cause of the autosomal recessive disorder phenylketonuria. Phe is the substrate for the PAH act...

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Autors principals:	Patel, D, Kopec, J, Fitzpatrick, F, McCorvie, T, Yue, W
Format:	Journal article
Publicat:	Nature Publishing Group 2016

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