Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme deficiency are the genetic cause of the autosomal recessive disorder phenylketonuria. Phe is the substrate for the PAH act...

Полное описание

Библиографические подробности
Главные авторы:	Patel, D, Kopec, J, Fitzpatrick, F, McCorvie, T, Yue, W
Формат:	Journal article
Опубликовано:	Nature Publishing Group 2016

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