Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain

The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme deficiency are the genetic cause of the autosomal recessive disorder phenylketonuria. Phe is the substrate for the PAH act...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Patel, D, Kopec, J, Fitzpatrick, F, McCorvie, T, Yue, W
Định dạng:	Journal article
Được phát hành:	Nature Publishing Group 2016

Những quyển sách tương tự

Structural features of the regulatory ACT domain of phenylalanine hydroxylase.
Bằng: Carla Carluccio, et al.
Được phát hành: (2013-01-01)

Dynamic regulation of phenylalanine hydroxylase
Bằng: Fuchs Julian E., et al.
Được phát hành: (2014-07-01)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
Bằng: Figg, WD, et al.
Được phát hành: (2021)

Genotypes of patients with phenylalanine hydroxylase deficiency in the Wisconsin Amish
Bằng: Jessica Scott Schwoerer, et al.
Được phát hành: (2018-06-01)

High Protein Diet and Phenylalanine Hydroxylase Activities in Rats
Bằng: Carty Michael P., et al.
Được phát hành: (1989-11-01)

Phenylalanine hydroxylase mRNA rescues the phenylketonuria phenotype in mice
Bằng: Maximiliano L. Cacicedo, et al.
Được phát hành: (2022-10-01)

Mutations of the phenylalanine hydroxylase gene in patients with phenylketonuria in Shanxi, China
Bằng: Yong-An Zhou, et al.
Được phát hành: (2012-01-01)

Optical Coherence Tomography to Assess Neurodegeneration in Phenylalanine Hydroxylase Deficiency
Bằng: Amelie S. Lotz-Havla, et al.
Được phát hành: (2021-12-01)

Engineered Escherichia coli platforms for tyrosine-derivative production from phenylalanine using phenylalanine hydroxylase and tetrahydrobiopterin-regeneration system
Bằng: Yasuharu Satoh, et al.
Được phát hành: (2023-07-01)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Bằng: Chowdhury, R, et al.
Được phát hành: (2016)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Bằng: Rasheduzzaman Chowdhury, et al.
Được phát hành: (2016-08-01)

Screening and mutation analysis of phenylalanine hydroxylase deficiency in newborns from Jiangxi province
Bằng: Baitao Zeng, et al.
Được phát hành: (2023-02-01)

The analysis of the phenylalanine hydroxylase gene mutations by sequencing and ARMS techniques in Turkish patients
Bằng: Umit Luleyap, et al.
Được phát hành: (2016-12-01)

Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants
Bằng: Neha Sarodaya, et al.
Được phát hành: (2022-08-01)

Phenylalanine 4-Hydroxylase Contributes to Endophytic Bacterium Pseudomonas fluorescens’ Melatonin Biosynthesis
Bằng: Jian Jiao, et al.
Được phát hành: (2021-11-01)

Evidence of the Phenylalanine Hydroxylase Involvement In Biosynthesis of Pteridines and Hydroxylation of Tryptophan in Drosophila melanogaster
Bằng: Alcaniz S., et al.
Được phát hành: (1995-08-01)

Chronic Immune Stimulation May Cause Moderate Impairment of Phenylalanine 4-hydroxylase
Bằng: Scholl-Bürgi S, et al.
Được phát hành: (2011-02-01)

The effect of tetrahydrobiopterin on the thermostability of human phenylalanine hydroxylase as studied by circular dichroism spectroscopy
Bằng: Thórólfsson Matthias, et al.
Được phát hành: (2000-05-01)

The phenylalanine hydroxylase locus: A marker for the history of phenylketonuria and human genetic diversity - Discussion
Bằng: Beighton, P, et al.
Được phát hành: (1996)

Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives
Bằng: Raquel R. Lopes, et al.
Được phát hành: (2021-03-01)

The spectrum of phenylalanine hydroxylase variants and genotype–phenotype correlation in phenylketonuria patients in Gansu, China
Bằng: Chuan Zhang, et al.
Được phát hành: (2023-04-01)

Strategies for Successful Long-Term Engagement of Adults With Phenylalanine Hydroxylase Deficiency Returning to the Clinic
Bằng: Janet Thomas MD, et al.
Được phát hành: (2017-09-01)

Structural Properties of Phenylalanine-Based Dimers Revealed Using IR Action Spectroscopy
Bằng: Iuliia Stroganova, et al.
Được phát hành: (2022-04-01)

Solation of phenylalanine ammonia lyase and cinnamate 4-hydroxylase genes from bayur medicinal plant /
Bằng: Aimi Amirah Abd Ajis, 1992-, author
Được phát hành: (2018)

Solation of phenylalanine ammonia lyase and cinnamate 4-hydroxylase genes from bayur medicinal plant /
Bằng: Aimi Amirah Abd Ajis, 1992-, author, et al.
Được phát hành: (2018)

P029: The effects of the pharmacological chaperone sepiapterin on phenylalanine hydroxylase activity of common variants in phenylketonuria*
Bằng: Søren Gersting, et al.
Được phát hành: (2023-01-01)

Impact of Fluorinated Ionic Liquids on Human Phenylalanine Hydroxylase—A Potential Drug Delivery System
Bằng: Márcia M. S. Alves, et al.
Được phát hành: (2022-03-01)

Molecular assessment and bioinformatic analysis of two common mutations of phenylalanine hydroxylase (PAH) gene by HRM
Bằng: M Amir, et al.
Được phát hành: (2017-06-01)

Gene mutations in children with phenylalanine hydroxylase deficiency: an analysis of 45 cases in some regions of Chongqing
Bằng: WANG Dongjuan, et al.
Được phát hành: (2021-05-01)

Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase
Bằng: Linnea K. M. Blomgren, et al.
Được phát hành: (2024-04-01)

Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation
Bằng: João Leandro, et al.
Được phát hành: (2017-07-01)

Genetic Diversity and Balancing Selection within the Human Phenylalanine Hydroxylase (PAH) Gene Region in Iranian Population
Bằng: A Haghighatnia, et al.
Được phát hành: (2012-05-01)

Genetic Diversity and Balancing Selection within the Human Phenylalanine Hydroxylase (PAH) Gene Region in Iranian Population
Bằng: J Mowla, et al.
Được phát hành: (2012-04-01)

Quantitative analysis by flow cytometry of green fluorescent protein-tagged human phenylalanine hydroxylase expressed in Dictyostelium
Bằng: Kim Hye-Lim, et al.
Được phát hành: (2017-12-01)

Phenylalanine Hydroxylase RNAi Knockdown Negatively Affects Larval Development, Molting and Swimming Performance of Salmon Lice
Bằng: Prashanna Guragain, et al.
Được phát hành: (2020-12-01)

Assessing the accuracy of California county level COVID-19 hospitalization forecasts to inform public policy decision making
Bằng: Lauren A. White, et al.
Được phát hành: (2023-04-01)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
Bằng: Figg, WD, et al.
Được phát hành: (2023)

Engineered phenylalanine hydroxylase coupled with an effective cofactor synthesis and regeneration system for high-yield production of 5-hydroxytryptophan
Bằng: Yulin Ai, et al.
Được phát hành: (2025-03-01)

Investigation of exon 4 mutations of phenylalanine hydroxylase gene in phenylketonuria patients in Guilan Province using PCR-sequencing
Bằng: Neda Pourvatan, et al.
Được phát hành: (2019-02-01)

The Predictive Value of Genetic Analyses in the Diagnosis of Tetrahydrobiopterin (BH4)-Responsiveness in Chinese Phenylalanine Hydroxylase Deficiency Patients
Bằng: Tianwen Zhu, et al.
Được phát hành: (2017-07-01)