Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain
The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme deficiency are the genetic cause of the autosomal recessive disorder phenylketonuria. Phe is the substrate for the PAH act...
| Príomhchruthaitheoirí: | , , , , |
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| Formáid: | Journal article |
| Foilsithe / Cruthaithe: |
Nature Publishing Group
2016
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