Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei

The predominant secretory cargo of bloodstream form Trypanosoma brucei is variant surface glycoprotein (VSG), comprising ~10% total protein and forming a dense protective layer. Blocking VSG translation using Morpholino oligonucleotides triggered a precise pre-cytokinesis arrest. We investigated the...

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Main Authors: Ooi, C, Smith, T, Gluenz, E, Wand, N, Vaughan, S, Rudenko, G
格式: Journal article
语言:English
出版: Wiley 2018