Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ve young adult pituitary stem cells leads to forma...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Springer Nature
2017
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