Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ve young adult pituitary stem cells leads to forma...

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Bibliographic Details
Main Authors: Gonzalez-Meljem, J, Haston, S, Carreno, G, Apps, J, Pozzi, S, Stache, C, Kaushal, G, Virasami, A, Panousopoulos, L, Mousavy-Gharavy, S, Guerrero, A, Rashid, M, Jani, N, Goding, C, Jacques, T, Adams, D, Gil, J, Andoniadou, C, Martinez-Barbera, J
Format: Journal article
Published: Springer Nature 2017

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