Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

<p>This research programme investigated the expression of prolyl hydroxylase (PHD) proteins in rodent tissues. The importance of PHD enzymes lies in their ability to render oxygen sensitivity to Hypoxia inducible factor (HIF), the principal mediator of intracellular oxygen homeostasis. The fir...

Podrobná bibliografie
Hlavní autor:	Wijeyekoon, JB
Další autoři:	Pugh, C
Médium:	Diplomová práce
Jazyk:	English
Vydáno:	2013
Témata:	Medical Sciences Clinical laboratory sciences

Podobné jednotky

Regulation of HIF: prolyl hydroxylases.
Autor: Stolze, I, a další
Vydáno: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Autor: Chowdhury, R, a další
Vydáno: (2016)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
Autor: McNeill, L, a další
Vydáno: (2002)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
Autor: Tuckerman, JR, a další
Vydáno: (2004)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Autor: Mole, D, a další
Vydáno: (2003)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Autor: Schlemminger, I, a další
Vydáno: (2003)

Tolerance in renal transplantation: is mixed chimerism the missing link?
Autor: Janes, S, a další
Vydáno: (2009)

Studies on HIF hydroxylases
Autor: Webb, J
Vydáno: (2008)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
Autor: Holt-Martyn, JP, a další
Vydáno: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Autor: Cockman, M, a další
Vydáno: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Autor: Matthew E Cockman, a další
Vydáno: (2019-09-01)

Cortical dynamics subserving visual apparent motion
Autor: Ahmed, B, a další
Vydáno: (2008)

Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners
Autor: Hongyan Deng, a další
Vydáno: (2024-06-01)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
Autor: Chan, M, a další
Vydáno: (2016)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
Autor: Yeh, TL, a další
Vydáno: (2017)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
Autor: Maria Savyuk, a další
Vydáno: (2020-07-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
Autor: Andrey A. Poloznikov, a další
Vydáno: (2021-01-01)

Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme
Autor: Holt-Martyn, J
Vydáno: (2018)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
Autor: Flashman, E, a další
Vydáno: (2010)

The role of CCL25 and CCR9 in intestinal inflammation
Autor: Wendt, E, a další
Vydáno: (2013)

Adaptive changes of influenza virus A/H5N1 neuraminidase in vitro and in vivo
Autor: Le Nguyen, T
Vydáno: (2014)

Angiogenesis in human lung tumours
Autor: Ferguson, ML
Vydáno: (2008)

Editorial commentary: Understanding BCG is the key to improving it
Autor: McShane, H
Vydáno: (2014)

Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis
Autor: Hlela, C
Vydáno: (2011)

Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury
Autor: Zhao-Ying Ding, a další
Vydáno: (2022-03-01)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
Autor: Chowdhury, R, a další
Vydáno: (2013)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
Autor: Lippl, K
Vydáno: (2018)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
Autor: Masson, N, a další
Vydáno: (2003)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
Autor: Takahiro Kambara, a další
Vydáno: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
Autor: Kiichi Hirota
Vydáno: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Autor: Kilian B. Kennel, a další
Vydáno: (2022-11-01)

Probing the molecular basis of melanopsin induced light sensitivity
Autor: Vachtsevanos, AN
Vydáno: (2012)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
Autor: Willam, C, a další
Vydáno: (2006)

Mechanistic studies on human prolyl hydroxylase domain 2
Autor: Fiorini, G
Vydáno: (2024)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
Autor: Figg, WD, a další
Vydáno: (2021)

Role of prolyl hydroxylase domain proteins in bone metabolism
Autor: David Wolf, a další
Vydáno: (2022-03-01)

Prolyl hydroxylases and therapeutics.
Autor: Smith, T, a další
Vydáno: (2010)

HR23B, a biomarker for HDAC inhibitors
Autor: Khan, OA
Vydáno: (2013)

Risk factors for haemorrhage in patients with haematological malignancies
Autor: Estcourt, LJ
Vydáno: (2014)

Synthesis And Characterization Of Potential Human Hypoxia Inducible Factor (Hif) Prolyl Hydroxylase Domain 2 (Phd-2) Inhibitors
Autor: Toh, Lee Roy
Vydáno: (2021)