Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

<p>This research programme investigated the expression of prolyl hydroxylase (PHD) proteins in rodent tissues. The importance of PHD enzymes lies in their ability to render oxygen sensitivity to Hypoxia inducible factor (HIF), the principal mediator of intracellular oxygen homeostasis. The fir...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Wijeyekoon, JB
Rannpháirtithe:	Pugh, C
Formáid:	Tráchtas
Teanga:	English
Foilsithe / Cruthaithe:	2013
Ábhair:	Medical Sciences Clinical laboratory sciences

Míreanna comhchosúla

Regulation of HIF: prolyl hydroxylases.
de réir: Stolze, I, et al.
Foilsithe / Cruthaithe: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
de réir: Chowdhury, R, et al.
Foilsithe / Cruthaithe: (2016)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
de réir: McNeill, L, et al.
Foilsithe / Cruthaithe: (2002)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
de réir: Tuckerman, JR, et al.
Foilsithe / Cruthaithe: (2004)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
de réir: Mole, D, et al.
Foilsithe / Cruthaithe: (2003)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
de réir: Schlemminger, I, et al.
Foilsithe / Cruthaithe: (2003)

Tolerance in renal transplantation: is mixed chimerism the missing link?
de réir: Janes, S, et al.
Foilsithe / Cruthaithe: (2009)

Studies on HIF hydroxylases
de réir: Webb, J
Foilsithe / Cruthaithe: (2008)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
de réir: Holt-Martyn, JP, et al.
Foilsithe / Cruthaithe: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
de réir: Cockman, M, et al.
Foilsithe / Cruthaithe: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
de réir: Matthew E Cockman, et al.
Foilsithe / Cruthaithe: (2019-09-01)

Cortical dynamics subserving visual apparent motion
de réir: Ahmed, B, et al.
Foilsithe / Cruthaithe: (2008)

Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners
de réir: Hongyan Deng, et al.
Foilsithe / Cruthaithe: (2024-06-01)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
de réir: Chan, M, et al.
Foilsithe / Cruthaithe: (2016)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
de réir: Yeh, TL, et al.
Foilsithe / Cruthaithe: (2017)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
de réir: Maria Savyuk, et al.
Foilsithe / Cruthaithe: (2020-07-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
de réir: Andrey A. Poloznikov, et al.
Foilsithe / Cruthaithe: (2021-01-01)

Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme
de réir: Holt-Martyn, J
Foilsithe / Cruthaithe: (2018)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
de réir: Flashman, E, et al.
Foilsithe / Cruthaithe: (2010)

The role of CCL25 and CCR9 in intestinal inflammation
de réir: Wendt, E, et al.
Foilsithe / Cruthaithe: (2013)

Adaptive changes of influenza virus A/H5N1 neuraminidase in vitro and in vivo
de réir: Le Nguyen, T
Foilsithe / Cruthaithe: (2014)

Angiogenesis in human lung tumours
de réir: Ferguson, ML
Foilsithe / Cruthaithe: (2008)

Editorial commentary: Understanding BCG is the key to improving it
de réir: McShane, H
Foilsithe / Cruthaithe: (2014)

Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis
de réir: Hlela, C
Foilsithe / Cruthaithe: (2011)

Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury
de réir: Zhao-Ying Ding, et al.
Foilsithe / Cruthaithe: (2022-03-01)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
de réir: Chowdhury, R, et al.
Foilsithe / Cruthaithe: (2013)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
de réir: Lippl, K
Foilsithe / Cruthaithe: (2018)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
de réir: Masson, N, et al.
Foilsithe / Cruthaithe: (2003)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
de réir: Takahiro Kambara, et al.
Foilsithe / Cruthaithe: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
de réir: Kiichi Hirota
Foilsithe / Cruthaithe: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
de réir: Kilian B. Kennel, et al.
Foilsithe / Cruthaithe: (2022-11-01)

Probing the molecular basis of melanopsin induced light sensitivity
de réir: Vachtsevanos, AN
Foilsithe / Cruthaithe: (2012)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
de réir: Willam, C, et al.
Foilsithe / Cruthaithe: (2006)

Mechanistic studies on human prolyl hydroxylase domain 2
de réir: Fiorini, G
Foilsithe / Cruthaithe: (2024)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
de réir: Figg, WD, et al.
Foilsithe / Cruthaithe: (2021)

Role of prolyl hydroxylase domain proteins in bone metabolism
de réir: David Wolf, et al.
Foilsithe / Cruthaithe: (2022-03-01)

Prolyl hydroxylases and therapeutics.
de réir: Smith, T, et al.
Foilsithe / Cruthaithe: (2010)

HR23B, a biomarker for HDAC inhibitors
de réir: Khan, OA
Foilsithe / Cruthaithe: (2013)

Risk factors for haemorrhage in patients with haematological malignancies
de réir: Estcourt, LJ
Foilsithe / Cruthaithe: (2014)

Transcription regulation of Nrp1 during endothelial cell differentiation
de réir: Zhao, Z
Foilsithe / Cruthaithe: (2014)