The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.

The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.

The pathogenic form of the cyclooxygenase (COX) enzyme, COX-2, is also constitutively present in the spinal cord and has been implicated in chronic pain states in rat and man. A number of COX-2 inhibitors, including celecoxib and rofecoxib, are already used in man for the treatment of inflammatory p...

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Bibliographic Details
Main Authors: Bingham, S, Beswick, P, Bountra, C, Brown, T, Campbell, I, Chessell, I, Clayton, N, Collins, S, Davey, P, Goodland, H, Gray, N, Haslam, C, Hatcher, J, Hunter, A, Lucas, F, Murkitt, G, Naylor, A, Pickup, E, Sargent, B, Summerfield, S, Stevens, A, Stratton, S, Wiseman, J
Format: Journal article
Language:English
Published: 2005

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