Gating at both ends and breathing in the middle: conformational dynamics of TolC.
Drug extrusion via efflux through a tripartite complex (an inner membrane pump, an outer membrane protein, and a periplasmic protein) is a widely used mechanism in Gram-negative bacteria. The outer membrane protein (TolC in Escherichia coli; OprM in Pseudomonas aeruginosa) forms a tunnel-like pore t...
| Main Authors: | , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
Elsevier
2008
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