Deep phenotyping of the Cdhr1−/− mouse validates its use in pre-clinical studies for human CDHR1-associated retinal degeneration
Purpose To validate the Cdhr1−/− mouse as a model for human CDHR1-associated retinal degeneration, which may present as cone-rod dystrophy or geographic atrophy. Methods Deep phenotyping of Cdhr1−/− (n = 56) and C57BL6J wildtype control mice (n = 45) was undertaken using in vivo multimodal retinal...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2021
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