Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression

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HIF1A is a transcription factor that plays a central role for the adaptation to tissue hypoxia and for the inflammatory response of myeloid cells, including DCs. HIF1A is stabilized by hypoxia but also by TLR ligands under normoxic conditions. The underlying signaling events leading to the accumulat...

書誌詳細
主要な著者:	Jantsch, J, Wiese, M, Schödel, J, Castiglione, K, Gläsner, J, Kolbe, S, Mole, D, Schleicher, U, Eckardt, K, Hensel, M, Lang, R, Bogdan, C, Schnare, M, Willam, C
フォーマット:	Journal article
言語:	English
出版事項:	2011

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