Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

Lipid availability within transmembrane nano-pockets of ion channels is linked with mechanosensation. However, the effect of hindering lipid-chain penetration into nano-pockets on channel structure has not been demonstrated. Here we identify nano-pockets on the large conductance mechanosensitive cha...

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Bibliographic Details
Main Authors: Kapsalis, C, Wang, B, El Mkami, H, Pitt, SJ, Schnell, JR, Smith, TK, Lippiat, JD, Bode, BE, Pliotas, C
Format: Journal article
Language:English
Published: Springer Nature 2019