ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres
Shelterin component TRF2 prevents ATM activation, while POT1 represses ATR signalling at telomeres. Here, we investigate the mechanism of G2/M arrest triggered by telomeres uncapped through TRF2 or POT1 inhibition in human cells. We find that telomere damage-activated ATR and ATM phosphorylate p53,...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
2012
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