Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

<p>The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. Here, we report that...

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Bibliographic Details
Main Authors:	Southcombe, J, Santos, A, Huo, J, Fernandes, R, Lever, M, Evans, E, Hudson, A, Chang, V, Hanke, T, Screaton, G, Fugger, L, Dushek, O, Xu, X, Davis, S, Jönsson, P, McColl, J, Godkin, A, Dunne, P, Horrocks, M, Palayret, M, Petersen, J, Rossjohn, J, Klenerman, D
Format:	Journal article
Published:	National Academy of Sciences 2016

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

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