Neutralizing autoantibodies against interleukin-10 in inflammatory bowel disease

Neutralizing autoantibodies against interleukin-10 in inflammatory bowel disease

We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling. After B-cell–depletion therapy and an associated decrease in the anti–interleukin-10 titer, conventi...

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Bibliographic Details
Main Authors: Griffin, H, Ceron-Gutierrez, L, Gharahdaghi, N, Ebrahimi, S, Davies, S, Loo, PS, Szabo, A, Williams, E, Mukhopadhyay, A, McLoughlin, L, Irwin, S, Travis, S, Klenerman, P, Bunn, S, Cant, AJ, Hambleton, S, Uhlig, HH, Doffinger, R
Format: Journal article
Language:English
Published: Massachusetts Medical Society 2024

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