Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus.

OBJECTIVES: Current models of clonal expansion in human Barrett's oesophagus are based upon heterogenous, flow-purified biopsy analysis taken at multiple segment levels. Detection of identical mutation fingerprints from these biopsy samples led to the proposal that a mutated clone with a select...

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מידע ביבליוגרפי
Main Authors: Leedham, S, Preston, S, McDonald, SA, Elia, G, Bhandari, P, Poller, D, Harrison, R, Novelli, MR, Jankowski, J, Wright, N
פורמט: Journal article
שפה:English
יצא לאור: 2008