D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.

The heroin analogue 1-methyl-4-phenylpyridinium, MPP(+), both in vitro and in vivo, produces death of dopaminergic substantia nigral cells by inhibiting the mitochondrial NADH dehydrogenase multienzyme complex, producing a syndrome indistinguishable from Parkinson's disease. Similarly, a fragme...

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Bibliographic Details
Main Authors: Kashiwaya, Y, Takeshima, T, Mori, N, Nakashima, K, Clarke, K, Veech, R
Format: Journal article
Language:English
Published: 2000