Targeting Wnt signaling in myeloma in vivo; Differential effects on tumor burden and myeloma bone disease

Targeting Wnt signaling in myeloma in vivo; Differential effects on tumor burden and myeloma bone disease

Bibliografische gegevens
Hoofdauteurs:	Edwards, C, Edwards, JR, Lwin, S, Mundy, G
Formaat:	Conference item
Gepubliceerd in:	2007

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Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo.
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EphB4 Expression in Osteoblasts is Regulated by Myeloma Cells and the Wnt Signaling Pathway.
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Wnt signaling: bone's defense against myeloma.
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Decreased bone marrow-derived adiponectin contributes to myeloma pathogenesis in vivo
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Lithium inhibits the development of myeloma bone disease in vivo.
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The importance of the bone marrow microenvironment in multiple myeloma; Differential responses to lithium in vivo
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#38. Cholesterol increases bone marrow tumour burden in myeloma in vivo and promotes myeloma cell viability and bortezomib resistance ex vivo
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Protein profiling in myeloma in vivo; Effects of bortezomib in a mouse model of myeloma
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Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease.
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Increasing adiponectin via an apolipoprotein peptide mimetic, L-4F, increases bone formation in normal mice and prevents myeloma bone disease in vivo
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The pathogenesis of the bone disease of multiple myeloma.
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Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1.
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Host-derived MMP-7 decreases myeloma progression in vivo: An unexpected role for MMP-7 and osteopontin in myeloma pathogenesis
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Osteoclasts in Myeloma Are Derived from Gr-1(+)CD11b(+) Myeloid Immune Suppressor Cells of the Bone Marrow Niche in Vivo
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The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo
door: Gámez, B, et al.
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Host Bone Marrow-Derived Stromal Cells Promote Myeloma Initiation and Development of Osteolysis
door: Fowler, J, et al.
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The ubiquitin-proteasome pathway is dysregulated in myeloma cells in the bone microenvironment in vivo
door: Edwards, C, et al.
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Novel therapeutic targets in myeloma bone disease.
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A loss of host-derived MMP-7 promotes myeloma growth and osteolytic bone disease in vivo
door: Lwin, S, et al.
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Myeloma cells exhibit an increase in proteasome activity and an enhanced response to proteasome inhibition in the bone marrow microenvironment in vivo.
door: Edwards, C, et al.
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The antidiabetic drug metformin acts on the bone microenvironment to promote myeloma cell adhesion to preosteoblasts and increase myeloma tumour burden in vivo
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Tumor-host cell interactions in the bone disease of myeloma.
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Myeloma cells decrease EphB4 expression in osteoblasts; A novel mechanism for regulation of bone formation in multiple myeloma
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Myeloma cells decrease EphB4 expression in osteoblasts: A novel mechanism for regulation of bone formation in multiple myeloma
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Advances in the management of myeloma bone disease.
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Diet-induced obesity promotes a myeloma-like condition in vivo.
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A murine model of myeloma that allows genetic manipulation of the host microenvironment.
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Osteoclasts in myeloma are derived from Gr-1+CD11b+mononuclear cells of the bone marrow niche
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Morphogens and growth factor signalling in the myeloma bone-lining niche
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Zoledronic Acid Inhibits the Capacity of Myeloid-Immune Suppressor Cells in Myeloma to Form Osteoclasts.
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The Bone Marrow Microenvironment in Multiple Myeloma
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Bone marrow adiposity and multiple myeloma
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Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells
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BTK inhibition in myeloma: targeting the seed and the soil.
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Prospective assessment of myeloma tumour burden and bone disease using DW-MRI and exploratory bone biomarkers
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Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential
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Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
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Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.
door: Junling Zhuang, et al.
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Dkk1 modulates osteoclastogenesis and bone resorption: Implications for myeloma bone disease.
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Bone-targeted agents in multiple myeloma
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Gepubliceerd in: (2018-03-01)