A short synthesis of aphanamol I in both racemic and enantiopure forms

A short synthesis of the biologically active sesquiterpene natural product (+)-aphanamol I in both racemic and enantiopure forms is reported. Key steps include: a catalytic enantioselective conjugate addition, an oxidative radical cyclisation, and a ringexpanding Claisen rearrangement.

ग्रंथसूची विवरण
मुख्य लेखकों: Burton, J, Ferrara, S
स्वरूप: Journal article
प्रकाशित: Wiley 2016
विवरण
सारांश:A short synthesis of the biologically active sesquiterpene natural product (+)-aphanamol I in both racemic and enantiopure forms is reported. Key steps include: a catalytic enantioselective conjugate addition, an oxidative radical cyclisation, and a ringexpanding Claisen rearrangement.