Potent T cell agonism mediated by a very rapid TCR/pMHC interaction.

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction.

The interaction between T cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) antigens can lead to varying degrees of agonism (T cell activation), or antagonism. The P14 TCR recognises the lymphocytic choriomeningitis virus (LCMV)-derived peptide, gp33 residues 33-41 (KAVYNFATC)...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Boulter, J, Schmitz, N, Sewell, A, Godkin, A, Bachmann, M, Gallimore, A
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2007

Eitemau Tebyg

Rapid screening of TCR-pMHC interactions by the YAMTAD system
gan: Lihui Wang, et al.
Cyhoeddwyd: (2022-04-01)

Microfluidic platform for characterizing TCR–pMHC interactions
gan: Stockslager, Max Andrew, et al.
Cyhoeddwyd: (2019)

TCR/pMHC interaction: phenotypic model for an unsolved enigma
gan: Jesus Galvez, et al.
Cyhoeddwyd: (2016-11-01)

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics
gan: Ashley M. Buckle, et al.
Cyhoeddwyd: (2018-12-01)

Information-Driven Docking for TCR-pMHC Complex Prediction
gan: Thomas Peacock, et al.
Cyhoeddwyd: (2021-06-01)

Force measurements of TCR/pMHC recognition at T cell surface.
gan: Pierre-Henri Puech, et al.
Cyhoeddwyd: (2011-01-01)

CD8 helps TCR catch slippery self pMHC
gan: Dushek, O, et al.
Cyhoeddwyd: (2018)

Molecular dynamics simulations reveal canonical conformations in different pMHC/TCR interactions
gan: Alba, J, et al.
Cyhoeddwyd: (2020)

Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions
gan: Josephine Alba, et al.
Cyhoeddwyd: (2020-04-01)

Structural features of the αβTCR mechanotransduction apparatus that promote pMHC discrimination
gan: Kristine N Brazin, et al.
Cyhoeddwyd: (2015-09-01)

Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex.
gan: Cyril F Reboul, et al.
Cyhoeddwyd: (2012-01-01)

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
gan: Geoff P O'Donoghue, et al.
Cyhoeddwyd: (2013-07-01)

Performance comparison of TCR-pMHC prediction tools reveals a strong data dependency
gan: Lihua Deng, et al.
Cyhoeddwyd: (2023-04-01)

The coordination of unprotonated peptide tertiary structure as a metric of pMHC–TCR functional avidity
gan: Georgios S.E. Antipas, et al.
Cyhoeddwyd: (2015-12-01)

The molecular mechanisms of CD8+ T cell responses to SARS-CoV-2 infection mediated by TCR-pMHC interactions
gan: Shasha Deng, et al.
Cyhoeddwyd: (2024-10-01)

Intramolecular Domain Movements of Free and Bound pMHC and TCR Proteins: A Molecular Dynamics Simulation Study
gan: Rudolf Karch, et al.
Cyhoeddwyd: (2019-07-01)

The identification of effective tumor-suppressing neoantigens using a tumor-reactive TIL TCR-pMHC ternary complex
gan: Sang Hoon Kim, et al.
Cyhoeddwyd: (2024-06-01)

The Full Model of the pMHC-TCR-CD3 Complex: A Structural and Dynamical Characterization of Bound and Unbound States
gan: Josephine Alba, et al.
Cyhoeddwyd: (2022-02-01)

<i>n</i>-3 Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR–pMHC Interaction of Anti-Viral CD8<sup>+</sup> T Cells
gan: Younghyun Lim, et al.
Cyhoeddwyd: (2020-06-01)

Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy
gan: Anna Fuller, et al.
Cyhoeddwyd: (2017-07-01)

Conformational flexibility of a free and TCR-bound pMHC-I protein investigated by long-term molecular dynamics simulations
gan: Lisa Tomasiak, et al.
Cyhoeddwyd: (2022-07-01)

Is TCR/pMHC Affinity a Good Estimate of the T-cell Response? An Answer Based on Predictions From 12 Phenotypic Models
gan: Jesús Gálvez, et al.
Cyhoeddwyd: (2019-03-01)

Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
gan: Egan, JR, et al.
Cyhoeddwyd: (2022)

Fluctuations in T cell receptor and pMHC interactions regulate T cell activation
gan: Egan, JR, et al.
Cyhoeddwyd: (2022)

Understanding TR binding to pMHC complexes: how does a TR scan many pMHC complexes yet preferentially bind to one.
gan: Javed Mohammed Khan, et al.
Cyhoeddwyd: (2011-01-01)

172 pMHC MD simulations of Knapp et al. 2015
gan: Knapp, B
Cyhoeddwyd: (2015)

Transfer learning improves pMHC kinetic stability and immunogenicity predictions
gan: Romanos Fasoulis, et al.
Cyhoeddwyd: (2024-03-01)

High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange
gan: Sarah A. Overall, et al.
Cyhoeddwyd: (2020-04-01)

TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding
gan: Limozin, L, et al.
Cyhoeddwyd: (2019)

MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity
gan: Naoko Imai, et al.
Cyhoeddwyd: (2024-11-01)

A Strategy for Selective Deletion of Autoimmunity-Related T Cells by pMHC-Targeted Delivery
gan: Shalom D. Goldberg, et al.
Cyhoeddwyd: (2021-10-01)

Conformation-selective rather than avidity-based binding to tumor associated antigen derived peptide-MHC enables targeting of WT1-pMHC low expressing cancer cells by anti-WT1-pMHC/CD3 T cell engagers
gan: Even Walseng, et al.
Cyhoeddwyd: (2023-11-01)

Targeting cancers through TCR-peptide/MHC interactions
gan: Qinghua He, et al.
Cyhoeddwyd: (2019-12-01)

Application of the pMHC Array to Characterise Tumour Antigen Specific T Cell Populations in Leukaemia Patients at Disease Diagnosis.
gan: Suzanne E Brooks, et al.
Cyhoeddwyd: (2015-01-01)

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC
gan: Hoerter, John A. H., et al.
Cyhoeddwyd: (2014)

Genetically engineered CD80–pMHC-harboring extracellular vesicles for antigen-specific CD4+ T-cell engagement
gan: Irina A. Ishina, et al.
Cyhoeddwyd: (2024-01-01)

Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8+ T cell detection
gan: Yueyang Sun, et al.
Cyhoeddwyd: (2022-07-01)

Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck
gan: Xiang Zhao, et al.
Cyhoeddwyd: (2021-10-01)

Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.
gan: Setterblad, N, et al.
Cyhoeddwyd: (2004)

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
gan: Minh Ngoc Duong, et al.
Cyhoeddwyd: (2019-11-01)