Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages.

Understanding the signalling mechanisms controlling inflammatory cytokine production is pivotal to the research of both acute and chronic immune disorders. Tyrosine phosphorylation is one of the earliest events to occur in response to an immune challenge yet the role of specific tyrosine kinases in...

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Bibliographic Details
Main Authors: Smolinska, M, Horwood, N, Page, T, Smallie, T, Foxwell, B
Format: Journal article
Language:English
Published: 2008