Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins.
The effect of replacing the beta-lactam carbonyl oxygen in cephalosporins by sulfur on their reactivity has been investigated. The second-order rate constant for alkaline hydrolysis of the sulfur analogue is 2-fold less than that for the natural cephalosporin. The thioxo derivative of cephalexin, wi...
Main Authors: | , , , |
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Format: | Journal article |
Language: | English |
Published: |
2004
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