Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.

Activity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by 2-oxoglutarate (2-OG)-dependent oxygenases mediates ubiquitinylation and proteasomal destruction of HIF-alpha. Hydro...

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Bibliographic Details
Main Authors:	Hewitson, K, McNeill, L, Riordan, M, Tian, Y, Bullock, A, Welford, R, Elkins, J, Oldham, N, Bhattacharya, S, Gleadle, J, Ratcliffe, P, Pugh, C, Schofield, C
Format:	Journal article
Language:	English
Published:	2002

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.

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