TRIM21/Ro52 - Roles in innate immunity and autoimmune disease
TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren’s syndrome, systemic lupus erythematosus, and other rheumatic autoimmune diseases. Here, we summarise the structur...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Frontiers Media
2021
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| _version_ | 1797072619778867200 |
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| author | Jones, EL Laidlaw, SM Dustin, LB |
| author_facet | Jones, EL Laidlaw, SM Dustin, LB |
| author_sort | Jones, EL |
| collection | OXFORD |
| description | TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren’s syndrome, systemic lupus erythematosus, and other rheumatic autoimmune diseases. Here, we summarise the structure and function of this enzyme, its roles in innate immunity, adaptive immunity and cellular homeostasis, the pathogenesis of autoimmunity against TRIM21, and the potential impacts of autoantibodies to this intracellular protein. |
| first_indexed | 2024-03-06T23:10:22Z |
| format | Journal article |
| id | oxford-uuid:6541265a-f2c8-4b10-9e44-3efe45c9ef53 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:10:22Z |
| publishDate | 2021 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:6541265a-f2c8-4b10-9e44-3efe45c9ef532022-03-26T18:24:22ZTRIM21/Ro52 - Roles in innate immunity and autoimmune diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6541265a-f2c8-4b10-9e44-3efe45c9ef53EnglishSymplectic ElementsFrontiers Media2021Jones, ELLaidlaw, SMDustin, LBTRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren’s syndrome, systemic lupus erythematosus, and other rheumatic autoimmune diseases. Here, we summarise the structure and function of this enzyme, its roles in innate immunity, adaptive immunity and cellular homeostasis, the pathogenesis of autoimmunity against TRIM21, and the potential impacts of autoantibodies to this intracellular protein. |
| spellingShingle | Jones, EL Laidlaw, SM Dustin, LB TRIM21/Ro52 - Roles in innate immunity and autoimmune disease |
| title | TRIM21/Ro52 - Roles in innate immunity and autoimmune disease |
| title_full | TRIM21/Ro52 - Roles in innate immunity and autoimmune disease |
| title_fullStr | TRIM21/Ro52 - Roles in innate immunity and autoimmune disease |
| title_full_unstemmed | TRIM21/Ro52 - Roles in innate immunity and autoimmune disease |
| title_short | TRIM21/Ro52 - Roles in innate immunity and autoimmune disease |
| title_sort | trim21 ro52 roles in innate immunity and autoimmune disease |
| work_keys_str_mv | AT jonesel trim21ro52rolesininnateimmunityandautoimmunedisease AT laidlawsm trim21ro52rolesininnateimmunityandautoimmunedisease AT dustinlb trim21ro52rolesininnateimmunityandautoimmunedisease |