A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling

A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling

Vascular remodeling to match arterial diameter to tissue requirements commonly fails in ischemic disease. Endothelial cells sense fluid shear stress (FSS) from blood flow to maintain FSS within a narrow range in healthy vessels. Thus, high FSS induces vessel outward remodeling, but mechanisms are po...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Springer Nature 2024

Παρόμοια τεκμήρια

BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions.
ανά: Laura Dyer, κ.ά.
Έκδοση: (2015-01-01)

Correction: BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions.
ανά: Laura Dyer, κ.ά.
Έκδοση: (2018-01-01)

KLF12 Aggravates Angiotensin II‐Induced Cardiac Remodeling in Male Mice by Transcriptionally Inhibiting SMAD7
ανά: Min Hu, κ.ά.
Έκδοση: (2025-02-01)

SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations
ανά: Kuheli Banerjee, κ.ά.
Έκδοση: (2023-09-01)

BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis
ανά: Jacob D. Garritson, κ.ά.
Έκδοση: (2023-06-01)

Expansion of the mutational spectrum of BMPER leading to diaphanospondylodysostosis and description of the associated disease process
ανά: Frederik Braun, κ.ά.
Έκδοση: (2021-12-01)

High Fluid Shear Stress Inhibits Cytokine‐Driven Smad2/3 Activation in Vascular Endothelial Cells
ανά: Hanqiang Deng, κ.ά.
Έκδοση: (2022-07-01)

BMPER Enhances Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells
ανά: Fei Xiao, κ.ά.
Έκδοση: (2018-03-01)

Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription
ανά: Jerome Jatzlau, κ.ά.
Έκδοση: (2023-09-01)

The adaptive remodeling of endothelial glycocalyx in response to fluid shear stress.
ανά: Ye Zeng, κ.ά.
Έκδοση: (2014-01-01)

Smooth muscle–derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis
ανά: Sizhao Lu, κ.ά.
Έκδοση: (2020-12-01)

Successfully Managed Respiratory Insufficiency in a Patient with a Novel Pathogenic Variant of the <i>BMPER</i> Gene: A Case Report
ανά: Ho Eun Park, κ.ά.
Έκδοση: (2022-03-01)

Creg1 Regulates Erythroid Development via TGF‐β/Smad2‐Klf1 Axis in Zebrafish
ανά: Xiao Han, κ.ά.
Έκδοση: (2024-09-01)

Effects of BMPER, CXCL10, and HOXA9 on Neovascularization During Early-Growth Stage of Primary High-Grade Glioma and Their Corresponding MRI Biomarkers
ανά: Wei Xue, κ.ά.
Έκδοση: (2020-05-01)

CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1
ανά: Shuai Mei, κ.ά.
Έκδοση: (2024-11-01)

CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1
ανά: Shuai Mei, κ.ά.
Έκδοση: (2024-07-01)

Effect of Fluid Shear Stress on Portal Vein Remodeling in a Rat Model of Portal Hypertension
ανά: Bin Wen, κ.ά.
Έκδοση: (2015-01-01)

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
ανά: Nicolas Baeyens, κ.ά.
Έκδοση: (2015-02-01)

JNK regulates muscle remodeling via myostatin/SMAD inhibition
ανά: Sarah J. Lessard, κ.ά.
Έκδοση: (2018-08-01)

Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats
ανά: Odile Dumont, κ.ά.
Έκδοση: (2014-01-01)

Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
ανά: Paul-Lennard Mendez, κ.ά.
Έκδοση: (2022-09-01)

Fluid Shear Stress and Inner Curvature Remodeling of the Embryonic Heart. Choosing the Right Lane!
ανά: Beerend P. Hierck, κ.ά.
Έκδοση: (2008-01-01)

The Partial Role of KLF4 and KLF5 in Gastrointestinal Tumors
ανά: Jun-Chen Li, κ.ά.
Έκδοση: (2021-01-01)

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
ανά: Ming-Li Zou, κ.ά.
Έκδοση: (2021-05-01)

Evolutionary Remodeling of Bacterial Motility Checkpoint Control
ανά: Bin Ni, κ.ά.
Έκδοση: (2017-01-01)

The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice
ανά: Cao Wang, κ.ά.
Έκδοση: (2023-02-01)

Pulsatile flow of shear-dependent fluid in a stenosed artery
ανά: Mandal Shankar Mani, κ.ά.
Έκδοση: (2012-01-01)

Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis
ανά: Hiroaki Suzuki, κ.ά.
Έκδοση: (2023-08-01)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
ανά: Adrien Bertrand-Chapel, κ.ά.
Έκδοση: (2022-10-01)

Shear stress induces autophagy in Schlemm’s canal cells via primary cilia-mediated SMAD2/3 signaling pathway
ανά: Myoung Sup Shim, κ.ά.
Έκδοση: (2023-12-01)

Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites
ανά: Roman Tsaryk, κ.ά.
Έκδοση: (2022-03-01)

Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway
ανά: Jun Zhao, κ.ά.
Έκδοση: (2024-11-01)

Bioresponsive and immunotherapeutic nanomaterials to remodel tumor microenvironment for enhanced immune checkpoint blockade
ανά: Tianxu Fang, κ.ά.
Έκδοση: (2024-02-01)

The Klf6-related super enhancer regulates Klf6-SV2 expression mediated proliferation in human hepatoma (HepG2) cells
ανά: Kum Chol Ri, κ.ά.
Έκδοση: (2019-10-01)

Shear stress leads to the dysfunction of endothelial cells through the Cav-1-mediated KLF2/eNOS/ERK signaling pathway under physiological conditions
ανά: Wang Lihua, κ.ά.
Έκδοση: (2023-04-01)

Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques
ανά: Antoniadis, Antonios P., κ.ά.
Έκδοση: (2017)

Persistent Hypoxia with Intermittent Aggravation Causes Imbalance in Smad3/Myocardin-Related Transcription Factor Signaling with Consequent Endothelial Senescence and Pulmonary Arterial Remodeling
ανά: Jiaxin Hu, κ.ά.
Έκδοση: (2023-08-01)

S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension
ανά: Yiqian Ban, κ.ά.
Έκδοση: (2019-02-01)

Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction
ανά: Mingkun Wang, κ.ά.
Έκδοση: (2023-04-01)

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart
ανά: Xueyu Li, κ.ά.
Έκδοση: (2020-04-01)