Revisiting dopamine-acetylcholine imbalance in Parkinson’s disease: glutamate co-transmission as an exciting partner in crime

Striatal dopamine and acetylcholine are thought to be imbalanced in Parkinson’s disease. In this issue of Neuron, Cai et al. report that restoration of nigral glutamate co-transmission, acting on dorsolateral striatalcholinergic interneuron mGluR1s, can rescue motor dysfunction in a mouse model of P...