Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

The 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases are a superfamily of enzymes that catalyse a wide range of reactions including hydroxylations, desaturations and oxidative ring closures. Recently, it has been discovered that they act as sensors in the hypoxic response in humans and oth...

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Bibliographic Details
Main Authors: Hewitson, K, Granatino, N, Welford, R, McDonough, M, Schofield, C
Format: Journal article
Language:English
Published: 2005