Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

The 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases are a superfamily of enzymes that catalyse a wide range of reactions including hydroxylations, desaturations and oxidative ring closures. Recently, it has been discovered that they act as sensors in the hypoxic response in humans and oth...

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Bibliografiske detaljer
Main Authors:	Hewitson, K, Granatino, N, Welford, R, McDonough, M, Schofield, C
Format:	Journal article
Sprog:	English
Udgivet:	2005

Lignende værker

The role of iron and 2-oxoglutarate oxygenases in signalling.
af: Hewitson, K, et al.
Udgivet: (2003)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases
af: Mantri, M, et al.
Udgivet: (2012)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases
af: Mantri, M, et al.
Udgivet: (2012)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases.
af: Mantri, M, et al.
Udgivet: (2012)

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.
af: Clifton, I, et al.
Udgivet: (2006)

Inhibition of 2-oxoglutarate dependent oxygenases.
af: Rose, N, et al.
Udgivet: (2011)

Structural studies on human 2-oxoglutarate dependent oxygenases.
af: McDonough, M, et al.
Udgivet: (2010)

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases.
af: Aik, W, et al.
Udgivet: (2012)

A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases.
af: McNeill, L, et al.
Udgivet: (2005)

2-oxoglutarate-dependent oxygenases
af: Islam, M, et al.
Udgivet: (2018)

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
af: Islam, MS, et al.
Udgivet: (2019)

Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans.
af: Welford, R, et al.
Udgivet: (2005)

Structural and stereoelectronic insights into oxygenase catalyzed formation of ethylene from 2-oxoglutarate
af: Zhang, Z, et al.
Udgivet: (2017)

Studies on non-haem ferrous-dependent oxygenases and oxidases.
af: Barlow, J, et al.
Udgivet: (1997)

Expanding chemical biology of 2-oxoglutarate oxygenases.
af: Loenarz, C, et al.
Udgivet: (2008)

Mechanistic studies on 2-oxoglutarate dependent oxygenases
af: Schofield, C, et al.
Udgivet: (1999)

2-Oxoglutarate oxygenases are inhibited by a range of transition metals.
af: Sekirnik, R, et al.
Udgivet: (2010)

Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans (FEBS 29930) (vol 579, pg 5170, 2005)
af: Welford, R, et al.
Udgivet: (2005)

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.
af: Schofield, C, et al.
Udgivet: (1999)

NMR studies on 2-oxoglutarate oxygenases
af: Leung, IKH
Udgivet: (2013)

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
af: Tarhonskaya, H, et al.
Udgivet: (2014)

The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
af: Thalhammer, A, et al.
Udgivet: (2012)

The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
af: Thalhammer, A, et al.
Udgivet: (2012)

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases.
af: Loenarz, C, et al.
Udgivet: (2011)

The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues.
af: Mantri, M, et al.
Udgivet: (2011)

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
af: Hopkinson, R, et al.
Udgivet: (2013)

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase.
af: Turnbull, J, et al.
Udgivet: (2004)

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.
af: Rotili, D, et al.
Udgivet: (2011)

Inhibition of JMJD6 by 2-oxoglutarate mimics
af: Islam, MS, et al.
Udgivet: (2021)

Crystallographic studies on 2-oxoglutarate dependent oxygenases
af: Aik, WS
Udgivet: (2014)

Mechanistic studies on 2-oxoglutarate dependent oxygenases
af: Szollossi, A
Udgivet: (2012)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
af: Hewitson, K, et al.
Udgivet: (2008)

Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease
af: Liu, H, et al.
Udgivet: (2022)

Redox, haem and CO in enzymatic catalysis and regulation
af: Ragsdale, Stephen W., et al.
Udgivet: (2013)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
af: Rabe, P, et al.
Udgivet: (2018)

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
af: Leung, I, et al.
Udgivet: (2013)

Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock.
af: Reade, M, et al.
Udgivet: (2005)

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
af: Frezza, C, et al.
Udgivet: (2011)

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
af: Frezza, C, et al.
Udgivet: (2011)

Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.
af: Krylova, S, et al.
Udgivet: (2012)