Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

The 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases are a superfamily of enzymes that catalyse a wide range of reactions including hydroxylations, desaturations and oxidative ring closures. Recently, it has been discovered that they act as sensors in the hypoxic response in humans and oth...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Hewitson, K, Granatino, N, Welford, R, McDonough, M, Schofield, C
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2005

Παρόμοια τεκμήρια

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Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases
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Έκδοση: (2012)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases
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Έκδοση: (2012)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases.
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Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.
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Έκδοση: (2006)

Inhibition of 2-oxoglutarate dependent oxygenases.
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Έκδοση: (2011)

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Έκδοση: (2010)

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases.
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Έκδοση: (2012)

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Έκδοση: (2005)

2-oxoglutarate-dependent oxygenases
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Έκδοση: (2018)

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Έκδοση: (2019)

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Έκδοση: (2005)

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Έκδοση: (2005)

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The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
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The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
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Έκδοση: (2012)

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The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues.
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Έκδοση: (2011)

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
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Έκδοση: (2013)

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase.
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A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.
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Έκδοση: (2021)

Crystallographic studies on 2-oxoglutarate dependent oxygenases
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Mechanistic studies on 2-oxoglutarate dependent oxygenases
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Έκδοση: (2012)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
ανά: Hewitson, K, κ.ά.
Έκδοση: (2008)

Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease
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Έκδοση: (2022)

Redox, haem and CO in enzymatic catalysis and regulation
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Έκδοση: (2018)

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
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Έκδοση: (2013)

Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock.
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Έκδοση: (2005)

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
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Έκδοση: (2011)

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
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Έκδοση: (2011)

Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.
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