Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

The 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases are a superfamily of enzymes that catalyse a wide range of reactions including hydroxylations, desaturations and oxidative ring closures. Recently, it has been discovered that they act as sensors in the hypoxic response in humans and oth...

Bibliografski detalji
Glavni autori:	Hewitson, K, Granatino, N, Welford, R, McDonough, M, Schofield, C
Format:	Journal article
Jezik:	English
Izdano:	2005

Slični predmeti

The role of iron and 2-oxoglutarate oxygenases in signalling.
od: Hewitson, K, i dr.
Izdano: (2003)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases
od: Mantri, M, i dr.
Izdano: (2012)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases
od: Mantri, M, i dr.
Izdano: (2012)

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases.
od: Mantri, M, i dr.
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Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.
od: Clifton, I, i dr.
Izdano: (2006)

Inhibition of 2-oxoglutarate dependent oxygenases.
od: Rose, N, i dr.
Izdano: (2011)

Structural studies on human 2-oxoglutarate dependent oxygenases.
od: McDonough, M, i dr.
Izdano: (2010)

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases.
od: Aik, W, i dr.
Izdano: (2012)

A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases.
od: McNeill, L, i dr.
Izdano: (2005)

2-oxoglutarate-dependent oxygenases
od: Islam, M, i dr.
Izdano: (2018)

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
od: Islam, MS, i dr.
Izdano: (2019)

Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans.
od: Welford, R, i dr.
Izdano: (2005)

Structural and stereoelectronic insights into oxygenase catalyzed formation of ethylene from 2-oxoglutarate
od: Zhang, Z, i dr.
Izdano: (2017)

Studies on non-haem ferrous-dependent oxygenases and oxidases.
od: Barlow, J, i dr.
Izdano: (1997)

Expanding chemical biology of 2-oxoglutarate oxygenases.
od: Loenarz, C, i dr.
Izdano: (2008)

Mechanistic studies on 2-oxoglutarate dependent oxygenases
od: Schofield, C, i dr.
Izdano: (1999)

2-Oxoglutarate oxygenases are inhibited by a range of transition metals.
od: Sekirnik, R, i dr.
Izdano: (2010)

Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans (FEBS 29930) (vol 579, pg 5170, 2005)
od: Welford, R, i dr.
Izdano: (2005)

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.
od: Schofield, C, i dr.
Izdano: (1999)

NMR studies on 2-oxoglutarate oxygenases
od: Leung, IKH
Izdano: (2013)

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
od: Tarhonskaya, H, i dr.
Izdano: (2014)

The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
od: Thalhammer, A, i dr.
Izdano: (2012)

The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
od: Thalhammer, A, i dr.
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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases.
od: Loenarz, C, i dr.
Izdano: (2011)

The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues.
od: Mantri, M, i dr.
Izdano: (2011)

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
od: Hopkinson, R, i dr.
Izdano: (2013)

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase.
od: Turnbull, J, i dr.
Izdano: (2004)

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.
od: Rotili, D, i dr.
Izdano: (2011)

Inhibition of JMJD6 by 2-oxoglutarate mimics
od: Islam, MS, i dr.
Izdano: (2021)

Crystallographic studies on 2-oxoglutarate dependent oxygenases
od: Aik, WS
Izdano: (2014)

Mechanistic studies on 2-oxoglutarate dependent oxygenases
od: Szollossi, A
Izdano: (2012)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
od: Hewitson, K, i dr.
Izdano: (2008)

Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease
od: Liu, H, i dr.
Izdano: (2022)

Redox, haem and CO in enzymatic catalysis and regulation
od: Ragsdale, Stephen W., i dr.
Izdano: (2013)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
od: Rabe, P, i dr.
Izdano: (2018)

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
od: Leung, I, i dr.
Izdano: (2013)

Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock.
od: Reade, M, i dr.
Izdano: (2005)

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
od: Frezza, C, i dr.
Izdano: (2011)

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
od: Frezza, C, i dr.
Izdano: (2011)

Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.
od: Krylova, S, i dr.
Izdano: (2012)