The aorta can act as a site of naıve CD41 T-cell priming
Aims - Aortic adaptive immunity plays a crucial role in atherosclerosis; however, the precise mechanisms leading to T cell activation in the arterial wall remain poorly understood. Methods and Results - Here we have identified naïve T cells in the aorta of wild-type and TCR transgenic mice and we d...
| Main Authors: | , , , , , , , , , , , , |
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| פורמט: | Journal article |
| יצא לאור: |
Oxford University Press
2019
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| _version_ | 1826276311746740224 |
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| author | Macritchie, N Grassia, G Noonan, J Cole, J Hughes, C Schroeder, J Benson, R Cochain, C Zernecke, A Guzik, T Monaco, C Garside, P Maffia, P |
| author_facet | Macritchie, N Grassia, G Noonan, J Cole, J Hughes, C Schroeder, J Benson, R Cochain, C Zernecke, A Guzik, T Monaco, C Garside, P Maffia, P |
| author_sort | Macritchie, N |
| collection | OXFORD |
| description | Aims - Aortic adaptive immunity plays a crucial role in atherosclerosis; however, the precise mechanisms leading to T cell activation in the arterial wall remain poorly understood. Methods and Results - Here we have identified naïve T cells in the aorta of wild-type and TCR transgenic mice and we demonstrate that naïve T cells can be primed directly in the vessel wall with a similar activation profile to splenic and lymphoid T cells. Aortic homing of naïve T cells is regulated at least in part by the P-selectin glycosylated ligand-1 (PSGL-1) receptor. In experimental atherosclerosis the aorta supports CD4+ T cell activation selectively driving Th1 polarization. By contrast, secondary lymphoid organs display Treg expansion. Conclusions - Our results demonstrate that the aorta can support T cell priming and that naïve T cells traffic between the circulation and vessel wall. These data underpin the paradigm that local priming of T cells specific for plaque antigens contributes to atherosclerosis progression. |
| first_indexed | 2024-03-06T23:12:03Z |
| format | Journal article |
| id | oxford-uuid:65d2f6f8-00b0-4a01-ace8-cd5cd6b424b2 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:12:03Z |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:65d2f6f8-00b0-4a01-ace8-cd5cd6b424b22022-03-26T18:28:06ZThe aorta can act as a site of naıve CD41 T-cell primingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:65d2f6f8-00b0-4a01-ace8-cd5cd6b424b2Symplectic Elements at OxfordOxford University Press2019Macritchie, NGrassia, GNoonan, JCole, JHughes, CSchroeder, JBenson, RCochain, CZernecke, AGuzik, TMonaco, CGarside, PMaffia, PAims - Aortic adaptive immunity plays a crucial role in atherosclerosis; however, the precise mechanisms leading to T cell activation in the arterial wall remain poorly understood. Methods and Results - Here we have identified naïve T cells in the aorta of wild-type and TCR transgenic mice and we demonstrate that naïve T cells can be primed directly in the vessel wall with a similar activation profile to splenic and lymphoid T cells. Aortic homing of naïve T cells is regulated at least in part by the P-selectin glycosylated ligand-1 (PSGL-1) receptor. In experimental atherosclerosis the aorta supports CD4+ T cell activation selectively driving Th1 polarization. By contrast, secondary lymphoid organs display Treg expansion. Conclusions - Our results demonstrate that the aorta can support T cell priming and that naïve T cells traffic between the circulation and vessel wall. These data underpin the paradigm that local priming of T cells specific for plaque antigens contributes to atherosclerosis progression. |
| spellingShingle | Macritchie, N Grassia, G Noonan, J Cole, J Hughes, C Schroeder, J Benson, R Cochain, C Zernecke, A Guzik, T Monaco, C Garside, P Maffia, P The aorta can act as a site of naıve CD41 T-cell priming |
| title | The aorta can act as a site of naıve CD41 T-cell priming |
| title_full | The aorta can act as a site of naıve CD41 T-cell priming |
| title_fullStr | The aorta can act as a site of naıve CD41 T-cell priming |
| title_full_unstemmed | The aorta can act as a site of naıve CD41 T-cell priming |
| title_short | The aorta can act as a site of naıve CD41 T-cell priming |
| title_sort | aorta can act as a site of naive cd41 t cell priming |
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