α-Synuclein and dopamine at the crossroads of Parkinson's disease.

α-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinal motor symptoms are linked to death of dopaminergic neurons in the nigrostriatal pathway. Here w...

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Bibliographic Details
Main Authors: Venda, L, Cragg, S, Buchman, V, Wade-Martins, R
Format: Journal article
Language:English
Published: 2010